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A team from the Universitat Politècnica de València (UPV) and the Spanish National Research Council (CSIC), belonging to the Research Institute for Molecular Imaging Technologies (I3M), has developed, together with the NITIUV Group of the La Fe Health Research Institute (IIS La Fe) in Valencia and the Biomechanics Institute of Valencia, a new device - in the prototype phase - to break up kidney stones.
Lithovortex is a low-cost, portable device capable of destroying stones non-invasively, thanks to the application of ultrasound - it transmits waves from the outside to focus them inside the body, on the stone. According to the tests, its application halves the time needed to break up a stone. In addition, the size and portability of this device would make the treatment of kidney stones an outpatient procedure without the need for large accessory equipment, as is currently the case.

A microscopic ‘pinch’ on the stone

As Noé Jiménez, a researcher at the I3M Institute (UPV-CSIC), explains, Lithovortex acts based on a new type of acoustic wave, vortex beams. "We could draw an analogy with a sound whirlpool, where the wave curls and spins on itself when it focuses on the stone. These beams can produce shear forces on kidney stones more efficiently than a conventional beam. It is as if they were to give a microscopic pinch inside the stone, and that pinch causes the stone to fragment into very fine pieces, breaking down into sand that is finally expelled through the urethra,’ explains Noé Jiménez.

The device incorporates a therapeutic head of high-intensity acoustic vortices mounted on an automated robotic arm and an imaging system to guide the treatment. ‘The advantage of using this type of beam is that, as they are so efficient, they allow the amplitude of the wave to be halved, and this also reduces the likelihood of producing lesions and pain in healthy tissue,’ adds Dr César David Vera Donoso, from the Urology Department at La Fe Hospital and head of the Integrated Translational Urological Research Centre of Valencia (NITIUV) at the IIS La Fe in Valencia, which carried out the initial study.

The main application is the fragmentation of kidney stones. Still, in the same way that it fragments these stones, it could fragment other important calcifications, such as, for example, calcification of the aortic valve.
To date, the I3M (UPV-CSIC) team has manufactured and validated the device with artificial stones. In collaboration with the Lithotripsy Unit of the La Fe Hospital in Valencia, the prototype has been validated ex vivo with real stones. Next year it will be validated in an animal model.

Awarded a prize

The development of this device has been possible thanks to a Valorisation project of the Valencian Innovation Agency (AVI, INNVA1/2022/37). In addition, Lithovortex was honoured at the XXXIV National Meeting of the Lithiasis and Endourology, Laparoscopy and Robotics Groups, where the work presented by Dr Álvaro José Beviá Romero, resident of the Urology Service of the Hospital La Fe, received the ‘Gabriel Valdivia Award’ for Technological Innovation or Surgical Technique.

Project page: https://i3m.csic.upv.es/research/stim/innva1202237-umil/

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